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Indication for Humulin R U-500

Humulin® R U-500 (Concentrated) is indicated as an adjunct to diet and exercise to improve glycemic control in adults and children with type 1 and type 2 diabetes mellitus.

Humulin R U-500 is useful for the treatment of insulin-resistant patients with diabetes requiring daily doses of more than 200 units, since a large dose may be administered subcutaneously in a reasonable volume.

Indications

Humulin R U-100 <(NPH human insulin, [rDNA origin], isophane suspension> is indicated as an adjunct to diet and exercise to improve glycemic control in adults and children with type 1 and type 2 diabetes mellitus.

Humulin R U-100 may be administered intravenously under proper medical supervision in a clinical setting for glycemic control.

Humulin N is an intermediate-acting human insulin indicated to improve glycemic control in adult and pediatric patients with diabetes mellitus.

Humulin 70/30 is an insulin indicated to improve glycemic control in adult patients with diabetes mellitus.

Select Safety Information for Humulin R U-500

  • Humulin R U-500 is contraindicated during episodes of hypoglycemia and in patients hypersensitive to Humulin R U-500 or any of its excipients.
  • Starting or changing insulin therapy should be done cautiously and only under medical supervision.
  • Humulin R U-500 contains 500 units of insulin in each milliliter (5 times more concentrated than Humulin R U-100). For Humulin R U-500, extreme caution must be observed in the measurement of dosage because inadvertent overdose may result in serious adverse reaction or life-threatening hypoglycemia.
  • Fluid retention and heart failure can occur with concomitant use of TZDs and Humulin R U-500.

*Hypothetical patient profile